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Principles of Ethylene Oxide Sterilization of Plastic Vaccine Bottles

Aug. 10, 2021

Vaccination for animals in advance is an effective way to reduce infectious diseases, and the quality of the vaccine will directly affect the immune effect. Plastic vaccine bottles are the main packaging method of inactivated veterinary vaccines. In order to ensure that the microbial limit and other indicators of the packaging meet the requirements of national standards, they must be sterilized by ethylene oxide after the packaging process is completed.


Principles of Ethylene Oxide Sterilization of Plastic Vaccine Bottles

10ml plastic injection vial


Ethylene oxide, also known as ethylene oxide, is a colorless liquid at low temperatures with an aromatic ether smell. It has a boiling point of 10.8°C, an odor threshold of 760 mg/m~1064 mg/m, and a density of 1.52; ethylene oxide is flammable and easy to Explosion, its minimum combustion concentration is 3%. The principle of ethylene oxide sterilization is through its interaction with sulfhydryl (-SH), amino (-NH2), hydroxyl (-OH) and carboxyl (-COOH) on protein molecules and imino (-NH-) on nucleic acid molecules. The alkylation reaction occurs, causing the protein to lose the reactive group, hindering the normal biochemical reaction and metabolism of the protein, leading to the death of microorganisms, thereby achieving the sterilization effect.


Principles of Ethylene Oxide Sterilization of Plastic Vaccine Bottles

50ml plastic PP injection vial



Ethylene oxide is an alkylating agent with strong penetrating power. It can use a variety of packaging materials and can be sterilized in the packaging state. It can kill various microorganisms (including bacteria, spores, viruses, and fungal spores) at room temperature. Etc.), suitable for biomedical polymer materials that are not resistant to high temperature treatment, such as natural rubber, polyethylene, polypropylene and polyvinyl chloride. The microbiological limit of the sterilized plastic vaccine bottle will meet the standard requirements, which can prevent the vaccine from being contaminated.
It should be noted that after the sterilization of the plastic vaccine bottle, the ethylene oxide gas discharged should be properly treated and meet environmental protection requirements, so that the residual ethylene oxide can be safely removed.

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