Dec. 03, 2020
How to ensure the sterility of veterinary vaccine bottles?
Sterile production environment
The production environment of vaccine bottles is different from other pharmaceutical packaging. The entire production process must be carried out under aseptic conditions. Therefore, the production workshop of plastic injection vials must meet the requirements of GMP to avoid that the air cleanliness during the production process cannot meet the requirements of the production process. ,create pollution.
Secondly, vaccine bottle manufacturers need to have a sound quality control and inspection system that can conduct all-round inspections of their products to ensure the scientificity of the "sterile inspection" or "microbial limit inspection" methods and the accuracy of the inspection results.
Sterilize the product after molding
Veterinary vaccine bottles must be sterilized after production and molding. Currently, veterinary vaccine bottles mainly adopt two sterilization methods: ethylene oxide and high temperature and high pressure. The ethylene oxide sterilization procedure needs to include preheating, pre-wetting, vacuuming, injecting vaporized ethylene oxide to reach a predetermined concentration, maintaining the sterilization time, clearing the ethylene oxide gas in the sterilization cabinet, and analyzing to remove the Residues of ethylene oxide in bacteria products.
High-pressure steam sterilization, high temperature and high-pressure sterilization, can not only kill general bacteria, fungi and other microorganisms, but also kill spores and spores. It is the most reliable and widely used physical sterilization method, mainly used for resistance High temperature items.
Sterile filling environment
The surface of the vaccine bottle in contact with the product must be sterilized before filling. During the filling process, the vaccine must not be contaminated by external conditions such as any equipment components or the surrounding environment. The sealing must be carried out in the sterilized area. Prevent microbial contamination.
The sterility of veterinary vaccine bottles is the first line of defense to ensure vaccine safety. It is related to the effectiveness of vaccine inoculation, and it is also related to the economic benefits of tens of millions of farmers. It is hoped that veterinary drug companies and vaccine bottle manufacturers will share With hard work, veterinary vaccines can play a safer and more effective role and help the healthy development of my country’s animal husbandry.