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Effect of autoclaved sterilization of plastic vaccine vial

Carrie Nov 06,2019 Share this post:

The production of animal oral liquid medicines and health care products is mostly sterilized by potting after preparation. The autoclaved sterilization conditions commonly used in oral liquid bottles are: 115 ° C, 30 min or 121 ° C, 20 min. The oral liquid bottle must have good heat resistance. Sex and rigidity, no deformation under steam sterilization conditions, so the current oral liquid packaging basically uses glass bottles, but the glass bottles are fragile, must be cleaned, dried, disinfected before filling, improve production cost.

plastic vaccine vial

Plastic vaccine vial is not easy to break, light weight, plastic bottles produced in a clean environment can be directly filled, can effectively save the common process and cost of oral liquid, but the heat resistance of plastic is not high, polypropylene is heat resistance. The last general-purpose plastic, the maximum use temperature can reach 130 °C, has the characteristics of non-toxic, low relative density, chemical resistance, good mechanical properties, easy processing and other excellent characteristics. Currently, the unmodified plastic oral liquid bottle has sterilization temperature although Below the maximum use temperature of PP materials, there is no national standard for high temperature sterilization of plastic oral liquid bottles. Generally speaking, sterilization at 110 degrees Celsius can meet the national standard for glass bottle sterilization!

If it is sterilized after filling, it will easily cause deformation of the plastic bottle, and it cannot meet the pressure steam sterilization requirements of the oral liquid. It is necessary to use modified PP material to improve its rigidity and heat resistance.

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