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Plastic vaccine vial high temperature sterilization

Carrie Oct 03,2019 Share this post:

The production of oral liquid medicines and health care products is mostly sterilized by potting after preparation. The high-pressure steam sterilization conditions commonly used in oral liquid bottles are: 115 ° C, 30 min or 121 ° C, 20 min. The vaccine vial must have good heat resistance. Sex and rigidity, no deformation under steam sterilization conditions, so the current oral liquid packaging basically uses glass bottles, but the glass bottles are fragile, must be cleaned, dried, disinfected before filling, improve production cost.


vaccine vial


Plastic oral liquid packaging is not easy to break, light weight, plastic bottles produced in a clean environment can be directly filled, can effectively save the common process and cost of oral liquid, but the heat resistance of plastic is not high, polypropylene is heat resistance The last general-purpose plastic, the maximum use temperature can reach 130 °C, has the characteristics of non-toxic, low relative density, chemical resistance, good mechanical properties, easy processing and other excellent characteristics. Currently, the unmodified plastic oral liquid bottle has sterilization temperature although Below the maximum use temperature of PP materials, there is no national standard for high temperature sterilization of plastic oral liquid bottles. Generally speaking, sterilization at 110 degrees Celsius can meet the national standard for glass bottle sterilization!

If the sterilization is carried out after filling, the plastic bottle is easily deformed, and the pressure steam sterilization treatment requirement of the oral liquid cannot be satisfied, and the modified PP material is required to improve the rigidity and heat resistance.


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