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Effervescent tablets development and packaging characteristics

Carrie Mar 15,2019 Share this post:

With the development of society and the continuous improvement of people's material and cultural living standards, the awareness of self-care is gradually increasing, and the requirements for further safe, effective and rational use of drugs are getting higher and higher. The dosage form also needs to be convenient to take, fast in effect, and biological utilization. A drug with high degree, accurate dosage, stable quality and easy to carry, transport and store.

In order to meet this demand, "dry liquid preparation" - effervescent tablets came into being, it gathered the essence of ordinary oral tablets and liquid preparations and made up for the deficiency of both, becoming a new type of dosage that consumers love. . The predecessor forms of oral effervescent tablets are foamed soda, blister, effervescent, effervescent and topical effervescent tablets.

Comparison of effervescent tablets and common tablet dosage forms

1. Comparison of disintegration and dissolution processes

1 Effervescent tablets: Effervescent tablets are placed in water in vitro, rapidly disintegrate, release a large amount of carbon dioxide gas, dissolved into a liquid, and generally have a disintegration time limit of 1 to 5 minutes.

 2 ordinary tablets: ordinary tablets such as sugar-coated tablets after oral administration, in the gastrointestinal drug

The coating layer slowly falls off into a plain tablet, and after slowly disintegrating and dissolving, the drug is released, generally taking 15 to 60 minutes.

2. Comparison of absorption rate and bioavailability

1 The process of oral effervescent tablets is as follows:

The effervescent tablet disintegrates and dissolves the drug in vitro. After oral administration, the liquid is distributed in a large area in the gastrointestinal tract, and is absorbed into the blood by the gastrointestinal tract for about 10 to 30 minutes, thereby reducing the local stimulation of the drug in the gastrointestinal tract, thereby reducing the side effect and achieving quick effect. Efficient effect.

3 ordinary tablets in vivo process is as follows:

Ordinary tablets in the in vitro solution of the drug has been slowly dissolved, in the gastrointestinal tract by the influence of the gastrointestinal fluid environment, the drug dissolution is more and more slow, resulting in long gastrointestinal retention, and then absorbed into the blood, to achieve effective blood drug concentration 2 to 3 hours, or even a day or two, this is not suitable for patients with acute or early colds.

The effervescent tablet cap, also known as the moisture-proof cap, is produced by injection molding process, with low-density polyethylene as the main raw material and complicated mold. At the top of the lid is a medicine chamber, which can store silica gel and molecular sieves, and has a moisture-proof function to ensure that the medicine is protected from moisture. The spring can be contracted to hold the tablet without shaking.

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